How do alterations in ER-mitochondria tethering causally contribute to neurodegeneration across different diseases?

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Description

While the abstract notes that altered ER-mitochondria tethering is a common hallmark of many neurodegenerative diseases, the causal relationship and shared pathogenic mechanisms remain unclear. This knowledge gap limits understanding of whether this represents a common therapeutic target.

Gap type: unexplained_observation Source paper: PINK1/Parkin Mediated Mitophagy, Ca (2020, International journal of molecular sciences, PMID:32150829)

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