Do other RNA-binding proteins regulate firing pattern plasticity in cholinergic neurons beyond Pum1?

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Description

While Pum1 is identified as a critical regulator of the tonic-to-burst transition, it’s unclear whether this represents a broader post-transcriptional regulatory network controlling cholinergic firing plasticity. Identifying additional RNA-binding protein regulators could reveal redundant pathways and more robust therapeutic targets.

Gap type: open_question Source paper: Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nicotine-withdrawal-induced anxiety. (2026, Neuron, PMID:41903536)

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