What are the specific molecular mechanisms by which Plk1 regulates spindle checkpoint proteins?

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Description

The abstract mentions that Plk1 regulates spindle checkpoint proteins but doesn’t explain the mechanistic details of this regulation. Understanding these mechanisms is crucial for comprehending how mitotic errors lead to genomic instability in dividing neural progenitors.

Gap type: unexplained_observation Source paper: Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis. (2006, Cancer research, PMID:16849530)

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