Why do microglia remain immunosuppressed while myeloid infiltrates become highly inflammatory during epileptogenesis?

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Description

The study reveals that microglia maintain a relatively quiescent state while infiltrating myeloid cells display strong pro-inflammatory profiles during early epileptogenesis. The molecular mechanisms controlling this differential activation state are unknown, yet understanding this could inform targeted anti-inflammatory therapies.

Gap type: unexplained_observation Source paper: Microglia are less pro-inflammatory than myeloid infiltrates in the hippocampus of mice exposed to status epilepticus. (2016, Glia, PMID:27246930)

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