How do therapeutic agents targeting VAPB-PTPIP51 achieve selectivity without disrupting normal MAM function?

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Priority

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85%

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Market price

50%

Description

The abstract mentions therapeutic interventions targeting this tether but doesn’t address how to modulate pathological changes while preserving essential MAM functions like calcium homeostasis and lipid metabolism. This selectivity challenge is crucial for drug development.

Gap type: open_question Source paper: Modulation of ER-mitochondria tethering complex VAPB-PTPIP51: Novel therapeutic targets for aging-associated diseases. (2024, Ageing research reviews, PMID:38719161)

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