What accounts for structural MRI's low sensitivity in early dementia despite its widespread clinical adoption?

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Description

The abstract notes that structural MRI has relatively low sensitivity for early and differential diagnosis despite being widely used clinically. Understanding the fundamental limitations of structural approaches versus molecular changes could guide optimal imaging strategy selection.

Gap type: unexplained_observation Source paper: The use of neuroimaging techniques in the early and differential diagnosis of dementia. (2024, Molecular psychiatry, PMID:37608222)

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