Why do validated PET tracers for α-synuclein and TDP-43 remain elusive despite ongoing development efforts?

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Description

The abstract identifies the lack of validated tracers for α-synuclein (LBD marker) and TDP-43 (FTD marker) as notable gaps with ongoing work. Understanding the specific technical barriers preventing successful tracer development is critical for advancing differential diagnosis of these dementia subtypes.

Gap type: open_question Source paper: The use of neuroimaging techniques in the early and differential diagnosis of dementia. (2024, Molecular psychiatry, PMID:37608222)

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