What is the molecular mechanism by which amino acids recruit TBK1 to lysosomes?

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Description

The study shows TBK1 is recruited to lysosomes in response to elevated amino acids but doesn’t explain the sensing mechanism or signaling pathway. Understanding this recruitment is crucial for comprehending how lysosomal signaling integrates metabolic status.

Gap type: unexplained_observation Source paper: Lysosomal TBK1 responds to amino acid availability to relieve Rab7-dependent mTORC1 inhibition. (2024, The EMBO journal, PMID:39103493)

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