What determines the anatomical specificity of PVALB+ vagal neurons for NEBs versus other lung structures?

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Description

PVALB+ vagal neurons specifically innervate NEBs rather than other mechanosensitive lung structures involved in the Hering-Breuer reflex. The developmental and molecular mechanisms governing this precise targeting are unknown but critical for understanding respiratory circuit organization.

Gap type: unexplained_observation Source paper: A vagal reflex evoked by airway closure. (2024, Nature, PMID:38448588)

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