How do NEBs mechanistically distinguish airway closure from other mechanical stimuli despite uniform PIEZO2 expression?

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Description

The study shows NEBs detect airway compression but not stretch, yet all NEBs uniformly express PIEZO2 mechanoreceptors. The molecular basis for this mechanical selectivity remains unexplained, which is crucial for understanding respiratory mechanosensation specificity.

Gap type: unexplained_observation Source paper: A vagal reflex evoked by airway closure. (2024, Nature, PMID:38448588)

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