How does P2Y2R activation simultaneously promote both neuroprotective and pro-inflammatory responses?

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Description

The abstract describes P2Y2R activation as both pro-inflammatory (glial activation, chronic inflammation contributing to neurodegeneration) and neuroprotective (increased non-amyloidogenic APP cleavage, cofilin phosphorylation). The mechanisms determining which response predominates are not explained, yet this is critical for therapeutic targeting.

Gap type: unexplained_observation Source paper: P2Y2 nucleotide receptor-mediated responses in brain cells. (None, None, PMID:20387013)

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