What determines whether microglia adopt beneficial vs. harmful phenotypes in chronic stress-induced AD pathology?

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Description

The abstract describes microglia having both detrimental roles (promoting inflammation, synaptic loss) and beneficial roles (Aβ clearance, neuroprotection) in AD under chronic stress, but the molecular switches governing this phenotypic decision remain unknown. Understanding these mechanisms is critical for developing targeted therapies that promote beneficial microglial functions while suppressing harmful ones.

Gap type: unexplained_observation Source paper: Chronic stress as a risk factor for Alzheimer’s disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress. (None, None, PMID:29992181)

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