Why do only 3-4% of MSP1 patients develop parkinsonism despite carrying the same VCP mutations?

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Description

The rarity of parkinsonism in MSP1 suggests additional factors determine phenotypic expression beyond VCP mutation alone. Identifying these modifying factors could predict which patients will develop parkinsonism and inform personalized treatment approaches.

Gap type: unexplained_observation Source paper: In-vivo evidence of synucleinopathy in parkinsonism due to VCP mutation. (2026, Journal of neural transmission (Vienna, Austria : 1996), PMID:40931262)

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