What mechanisms determine why some epilepsy gene therapies succeed in preclinical models but face clinical translation challenges?

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Priority

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85%

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Market price

50%

Description

The abstract notes positive preclinical results with some progressing to clinical studies, yet identifies ongoing challenges with vectors, models, and clinical application. The mechanistic basis for this translation gap remains unexplained.

Gap type: unexplained_observation Source paper: Recent advances and current status of gene therapy for epilepsy. (2024, World journal of pediatrics : WJP, PMID:39395088)

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