What molecular mechanisms cause interneuron dysfunction to occur upstream of amyloid-β pathology in AD?

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Description

The abstract states that interneuron dysfunction may precede amyloid-β pathology, contradicting the traditional amyloid cascade hypothesis. Understanding these upstream mechanisms could reveal novel therapeutic targets that act before classic AD pathology emerges.

Gap type: unexplained_observation Source paper: Regional interneuron transcriptional changes reveal pathologic markers of disease progression in a mouse model of Alzheimer’s disease. (None, None, PMID:37961679)

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