Do CD11c+ cells actively uptake alpha-synuclein aggregates or acquire them through other mechanisms?

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Description

While CD11c+ cells contain alpha-synuclein in the ileum, it’s unclear whether these immune cells actively phagocytose the aggregates, receive them through cell-to-cell transfer, or acquire them via other pathways. This distinction is crucial for understanding the role of neuroinflammation in protein propagation.

Gap type: unexplained_observation Source paper: Brain-to-gut trafficking of alpha-synuclein by CD11c (None, None, PMID:37981650)

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