What drives age-related GSK3β overexpression and hyperactivation in podocytes?

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Description

The study demonstrates that GSK3β becomes overexpressed and hyperactive with age, but the upstream molecular triggers of this age-related dysregulation are not identified. This knowledge gap limits understanding of the initial events in kidney aging.

Gap type: unexplained_observation Source paper: Age-related GSK3β overexpression drives podocyte senescence and glomerular aging. (None, None, PMID:35166234)

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