How do retinal tau pathology patterns compare to brain tau pathology in the same mutation carriers?

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Description

While the study demonstrates retinal tau aggregation and dysfunction in MAPT IVS 10+16 mutation, it’s unclear whether retinal pathology mirrors or precedes brain pathology. This knowledge gap limits the retina’s utility as an early diagnostic biomarker for frontotemporal dementia.

Gap type: open_question Source paper: Understanding retinal tau pathology through functional 2D and 3D iPSC-derived in vitro retinal models. (2025, Acta neuropathologica communications, PMID:39881365)

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