Why does plasma GFAP lose correlation with AD pathology in advanced disease stages?

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Description

The study suggests GFAP-pathology associations plateau during advanced AD phases, but the underlying mechanism is unexplained. Understanding this could reveal critical insights about astrocytic responses and biomarker limitations in disease progression.

Gap type: unexplained_observation Source paper: Plasma glial fibrillary acidic protein in the visual and language variants of Alzheimer’s disease. (2024, Alzheimer’s & dementia : the journal of the Alzheimer’s Association, PMID:38528318)

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