What drives the weak correlation between plasma GFAP and tau accumulation rates?

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Description

The study found limited positive correlation between GFAP and tau progression, particularly fragile to outliers. The mechanistic basis for this weak relationship remains unclear, hindering GFAP’s utility for monitoring disease progression.

Gap type: unexplained_observation Source paper: Plasma glial fibrillary acidic protein in the visual and language variants of Alzheimer’s disease. (2024, Alzheimer’s & dementia : the journal of the Alzheimer’s Association, PMID:38528318)

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