Why does HDAC9 expression specifically decline with age in neurons?

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Description

The abstract reports age-related decline in neuronal HDAC9 expression but doesn’t explain the underlying cause. This gap is important because understanding why HDAC9 decreases could reveal upstream targets for intervention in cognitive aging.

Gap type: unexplained_observation Source paper: Neuronal HDAC9: A key regulator of cognitive and synaptic aging, rescuing Alzheimer’s disease-related phenotypes. (2026, Mol Psychiatry, PMID:41935184)

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