What molecular mechanism explains how FB1 inhibits ceramide synthases?

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Description

The authors explicitly state that the molecular mechanism of CerS inhibition by FB1 remains unknown, despite its well-established inhibitory effects. Understanding this mechanism is crucial for developing targeted interventions and predicting toxicity patterns.

Gap type: open_question Source paper: New insights into the organ-specific adverse effects of fumonisin B1: comparison between lung and liver. (2015, Archives of toxicology, PMID:25155190)

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