How does transcriptional dysregulation of HCN channels mechanistically contribute to epileptogenesis?

epilepsy/channelopathy open
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Description

While the authors suggest HCN transcriptional dysregulation contributes to epileptogenic processes, the specific causal mechanisms linking altered gene expression to seizure generation remain undefined. This mechanistic gap limits development of HCN-targeted antiepileptic therapies.

Gap type: unexplained_observation Source paper: Gene expression of the HCN family in rats with pilocarpine-induced epilepsy and in human hippocampal and cortical tissue. (2026, Brain research, PMID:41903877)

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