Why does PLA2G4C polymorphism show no impact on treatment response unlike other PLA2 variants?

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Description

While PLA2G4A and PLA2G6 polymorphisms significantly influence antipsychotic response, PLA2G4C shows no effect despite being in the same enzyme family. This differential impact suggests unknown functional differences between PLA2 isoforms in psychosis treatment that warrant investigation.

Gap type: unexplained_observation Source paper: Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients. (2023, Prostaglandins, leukotrienes, and essential fatty acids, PMID:37290257)

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