Why do PLA2 polymorphism effects on antipsychotic response manifest in a gender-specific manner?

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Description

The abstract reports gender-specific effects of PLA2 polymorphisms on treatment response, but provides no mechanistic explanation for this sex dimorphism. This gap limits understanding of how biological sex modulates pharmacogenomic responses in psychotic disorders.

Gap type: unexplained_observation Source paper: Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients. (2023, Prostaglandins, leukotrienes, and essential fatty acids, PMID:37290257)

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