What are the molecular mechanisms underlying UBE3A secretion and its functional significance?

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Description

The abstract identifies UBE3A secretion as a newly discovered pattern but provides no mechanistic explanation. Understanding how an E3 ligase is secreted and functions extracellularly could reveal novel therapeutic targets for neurodevelopmental and neurodegenerative diseases.

Gap type: unexplained_observation Source paper: Unraveling the Roles of UBE3A in Neurodevelopment and Neurodegeneration. (2025, International journal of molecular sciences, PMID:40076922)

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