What are the specific post-transcriptional mechanisms that mediate distant protein QTL effects?

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Description

The study identifies distinct transcriptional and post-transcriptional models underlying pQTL effects, with twice as many local as distant variants. However, the specific molecular mechanisms by which distant genetic variants regulate protein abundance through post-transcriptional pathways remain unexplained, limiting therapeutic targeting strategies.

Gap type: unexplained_observation Source paper: Defining the consequences of genetic variation on a proteome-wide scale. (2016, Nature, PMID:27309819)

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