Why do 9.1% of Parkinson's patients without traditional risk factors carry pathogenic variants?

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Description

The study found substantial genetic variant prevalence in patients lacking early onset, high-risk ancestry, or family history. This challenges current risk stratification models and suggests unknown factors influencing genetic susceptibility patterns in Parkinson’s disease.

Gap type: unexplained_observation Source paper: Parkinson’s disease variant detection and disclosure: PD GENEration, a North American study. (None, None, PMID:39074992)

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