What is the molecular mechanism by which Nptx2 binding to C1q inhibits complement activation?

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Description

The abstract shows Nptx2 binds C1q and regulates complement activity, but the specific molecular mechanism of how this binding inhibits complement cascade activation is not explained. Understanding this mechanism is crucial for developing targeted therapeutics that could modulate complement activity in neurodegeneration.

Gap type: unexplained_observation Source paper: The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration. (None, None, PMID:36989373)

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