How does Nptx2-mediated complement regulation differ between physiological and pathological conditions?

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Description

While the study shows Nptx2 restrains complement activity in disease models, it’s unclear how this regulatory mechanism operates under normal physiological conditions versus neurodegeneration. This distinction is critical for understanding when and how this protective mechanism fails in disease.

Gap type: open_question Source paper: The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration. (None, None, PMID:36989373)

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