What molecular mechanisms allow Cdk5 inhibition to unmask LTP in striatal neurons during early neurodegeneration?

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Description

The finding that Cdk5 inhibition can convert LTD-dominant striatal plasticity to LTP represents a potentially novel therapeutic target. However, the downstream signaling pathways and molecular switches that enable this plasticity reversal remain unexplained, limiting translational potential.

Gap type: unexplained_observation Source paper: Exploring the role of Cdk5 on striatal synaptic plasticity in a 3-NP-induced model of early stages of Huntington’s disease. (2024, Frontiers in molecular neuroscience, PMID:39569019)

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