How does anterograde transport of damaged mitochondria contribute to distal axon vulnerability?

neurodegeneration open
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Description

The abstract describes injured mitochondria moving anterogradely and accumulating in distal axons, but the mechanisms controlling this transport and how it amplifies axonal degeneration are not explained. This process may be key to understanding why distal axons are preferentially affected in PLAN and similar disorders.

Gap type: unexplained_observation Source paper: Neuroaxonal dystrophy in PLA2G6 knockout mice. (2015, Neuropathology : official journal of the Japanese Society of Neuropathology, PMID:25950622)

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