What are the specific molecular mechanisms by which circadian clocks regulate BBB permeability?

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Description

The abstract states that circadian clocks temporally regulate BBB permeability but does not explain the mechanistic basis for this regulation. Understanding these mechanisms is critical for developing chronotherapy approaches for neurological diseases and optimizing drug delivery timing.

Gap type: unexplained_observation Source paper: A circadian clock regulates the blood-brain barrier across phylogeny. (2024, Vitamins and hormones, PMID:39029975)

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