What molecular mechanisms drive age-associated epigenetic drift and its relationship to DNA methylation as an aging biomarker?

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Description

The authors explicitly state this is a ‘key missing piece of information’ - the mechanistic basis for how epigenetic drift occurs and relates to methylation-based aging biomarkers. Understanding these mechanisms is critical for interpreting aging biomarkers and potential interventions.

Gap type: open_question Source paper: Human brain aging is associated with dysregulation of cell type epigenetic identity. (2025, GeroScience, PMID:39730969)

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