Why are highly cell-type-differentiated CpGs more susceptible to age-related methylation changes than epigenetic clock CpGs?

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Description

The study reveals that CpGs defining cell identity show greater age-related changes while epigenetic clock CpGs are less cell-type-specific, but the underlying reason for this differential susceptibility is unexplained. This could inform why certain cell types are more vulnerable in neurodegeneration.

Gap type: unexplained_observation Source paper: Human brain aging is associated with dysregulation of cell type epigenetic identity. (2025, GeroScience, PMID:39730969)

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