Why are children disproportionately vulnerable to organophosphate neurotoxicity compared to adults?

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Description

The abstract states that children are much more susceptible to OP neurotoxic effects than adults, but the developmental or physiological basis for this age-dependent vulnerability is not mechanistically explained. This knowledge gap limits our ability to develop age-appropriate protective strategies.

Gap type: unexplained_observation Source paper: Long-Term Neuropsychiatric Developmental Defects after Neonatal Organophosphate Exposure: Mitigation by Synthetic Neurosteroids. (2024, The Journal of pharmacology and experimental therapeutics, PMID:37863488)

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