What determines which autophagy pathway defects are primary versus secondary in PD pathogenesis?

neurodegeneration open
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Description

While impaired autophagy is linked to neuronal death in PD, it’s unclear whether autophagy dysfunction initiates disease or results from other pathological processes. This distinction is essential for determining whether autophagy modulators can be disease-modifying versus merely symptomatic.

Gap type: unexplained_observation Source paper: Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson’s disease. (2021, Acta pharmaceutica Sinica. B, PMID:34729301)

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