Do other 'synaptic' ASD risk genes also have non-synaptic functions during early neurodevelopment?

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Description

This work suggests SYNGAP1’s non-synaptic role may represent a broader pattern among ASD-associated synaptic genes. Systematic investigation of other synaptic ASD genes during neurogenesis could reveal convergent non-synaptic mechanisms underlying ASD pathophysiology.

Gap type: open_question Source paper: Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis. (None, None, PMID:37946050)

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