What are the downstream signaling pathways affected by CD33 isoform switching in microglia during AD progression?

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Description

While CD33 isoform expression changes are linked to AD risk, the specific microglial signaling cascades and functional outcomes affected by this isoform switching remain unknown. This knowledge is essential for understanding CD33’s role in neuroinflammation.

Gap type: open_question Source paper: Evaluation of CD33 as a genetic risk factor for Alzheimer’s disease. (2019, Acta neuropathologica, PMID:30949760)

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