How does rutin's promotion of microglial function relate to its anti-inflammatory effects?

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Description

The abstract mentions that rutin both promotes microglial uptake of tau and reduces proinflammatory cytokines, but this appears contradictory since microglial activation typically increases inflammation. The mechanism reconciling enhanced microglial function with reduced neuroinflammation needs clarification.

Gap type: contradiction Source paper: Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease. (None, None, PMID:34116706)

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