How does TFQA binding to TrkB receptor lead to BDNF upregulation given that TrkB is typically a BDNF target?

neurotrophin signaling open
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Description

The study shows TFQA binds TrkB receptor and increases BDNF expression, but TrkB is normally activated by BDNF, not an upstream regulator of BDNF synthesis. This apparent reversal of the canonical BDNF-TrkB signaling axis requires mechanistic explanation.

Gap type: unexplained_observation Source paper: A novel synthetic 3,4,5-tri-feruloylquinic acid enhances learning and memory via neurotrophin signaling in an aging model senescence-accelerated prone 8 mice. (2026, GeroScience, PMID:40699486)

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