What endosomal mechanisms mediate enhanced tau release from AD synapses upon depolarization?

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Description

While the authors hypothesize endosomal release of tau peptides from AD synapses and demonstrate increased tau release upon depolarization, the specific endosomal pathways and regulatory mechanisms remain unexplored. This knowledge gap limits understanding of how tau pathology spreads trans-synaptically in AD.

Gap type: open_question Source paper: Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer’s disease. (2015, Journal of neurochemistry, PMID:25393609)

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