How does synaptic tau abundance reconcile with the established dogma of tau as primarily an axonal protein?

neurodegeneration open
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Description

The finding that most synaptic terminals are highly immunolabeled for tau contradicts the long-held view of tau as predominantly localized to axons. This challenges fundamental understanding of tau’s cellular distribution and suggests unrecognized synaptic functions that may be central to AD pathogenesis.

Gap type: contradiction Source paper: Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer’s disease. (2015, Journal of neurochemistry, PMID:25393609)

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