What molecular mechanisms drive C-terminal truncation of tau specifically at synaptic terminals?

synaptic biology open
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Description

The study shows that 75-85% of synaptic tau lacks its C-terminus, but the specific proteases and pathways responsible for this selective cleavage at synapses remain unknown. Understanding this mechanism is critical since C-terminal truncation may facilitate both tau aggregation and trans-synaptic spread in AD.

Gap type: unexplained_observation Source paper: Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer’s disease. (2015, Journal of neurochemistry, PMID:25393609)

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