What determines the regional specificity of calcification and cortical malformation in BLC-PMG?

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Description

The syndrome shows a characteristic symmetrical, predominantly fronto-parietal distribution of polymicrogyria and specific calcification patterns in deep gray matter and basal ganglia. The molecular basis for this regional vulnerability despite ubiquitous OCLN expression is unknown.

Gap type: unexplained_observation Source paper: Comprehensive molecular screening strategy of OCLN in band-like calcification with simplified gyration and polymicrogyria. (None, None, PMID:28386946)

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