What determines whether stress granules remain transient versus becoming persistent and pathological?

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79%

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85%

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70%

Market price

50%

Description

The abstract links persistent stress granules to pathological inclusions but doesn’t explain what factors control the persistence versus dissolution of stress granules. This knowledge gap is fundamental to understanding why some cellular stress responses become maladaptive in neurodegenerative diseases.

Gap type: open_question Source paper: Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization. (2015, Cell, PMID:26406374)

Evidence summary

Resolved by hypothesis h-fc1cd0d4bd: H6: Aberrant eIF2α Phosphorylation Creates Stalled Translation State. Score: 0.856. Supporting PMIDs: 25533948, 26142691, 25239947, 26804002, N/A, 31204559.

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