Why does human hippocampal neurogenesis persist with aging while it declines in rodents and primates?

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Description

This study contradicts established findings that adult neurogenesis declines with aging across mammalian species. The species-specific difference in aging patterns could reveal unique human brain maintenance mechanisms with implications for cognitive preservation and therapeutic targets.

Gap type: contradiction Source paper: Human Hippocampal Neurogenesis Persists throughout Aging. (2018, Cell stem cell, PMID:29625071)

Resolution criteria

Resolved when persistent human adult hippocampal neurogenesis is validated or refuted with harmonized cross-species methods. Required evidence: postmortem human hippocampus processed with fixation-delay controls, multiple immature-neuron/proliferation markers, single-nucleus or spatial transcriptomics, age-stratified quantification, and direct comparison to rodent and nonhuman primate datasets using matched pipelines. Closure requires showing whether the human signal reflects true neurogenesis, delayed maturation, or technical differences.

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