Why does neurogenesis decline selectively in anterior-mid but not posterior dentate gyrus with aging?

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Description

The regional specificity of aging effects within the dentate gyrus suggests distinct regulatory mechanisms or functional demands across hippocampal subregions. Understanding this spatial pattern could reveal targeted intervention points for age-related cognitive decline.

Gap type: unexplained_observation Source paper: Human Hippocampal Neurogenesis Persists throughout Aging. (2018, Cell stem cell, PMID:29625071)

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