What mechanisms maintain neurogenesis despite reduced angiogenesis and smaller progenitor pools in aging?

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Description

The study shows preserved neurogenesis occurs alongside decreased angiogenesis and reduced quiescent progenitors in older individuals. The compensatory mechanisms that maintain neurogenic output under these constraints are unknown but could inform regenerative strategies.

Gap type: unexplained_observation Source paper: Human Hippocampal Neurogenesis Persists throughout Aging. (2018, Cell stem cell, PMID:29625071)

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