How does cordycepin simultaneously inhibit PI3K/AKT/mTOR while promoting autophagy given mTOR's role as autophagy suppressor?

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Description

The study shows cordycepin inhibits PI3K/AKT/mTOR signaling while enhancing autophagy proteins, which aligns with mTOR’s known autophagy-suppressive role. However, the specific molecular mechanisms by which cordycepin coordinates these effects and whether additional autophagy pathways are involved remains unexplained.

Gap type: unexplained_observation Source paper: Neuroprotective effects of cordycepin on MPTP-induced Parkinson’s disease mice via suppressing PI3K/AKT/mTOR and MAPK-mediated neuroinflammation. (2024, Free radical biology & medicine, PMID:38479634)

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